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Ultrasound-assisted fabrication of a biocompatible magnetic hydroxyapatite

Ultrasound-assisted fabrication of a biocompatible magnetic hydroxyapatite

作者:Zhou, G (Zhou, Gang)[ 1,2 ] ; Song, W (Song, Wei)[ 1,2 ] ; Hou, YZ (Hou, Yongzhao)[ 1 ] ; Li, Q (Li, Qing)[ 1,3 ] ; Deng, XL (Deng, Xuliang)[ 4 ] ; Fan, YB(Fan, Yubo)[ 1,2 ]

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

卷: 102

 

期: 10

 

页: 3704-3712

DOI: 10.1002/jbm.a.35043

出版年: OCT 2014

查看期刊信息

摘要

This work describes the fabrication and characterization of a biocompatible magnetic hydroxyapatite (HA) using an ultrasound-assisted co-precipitation method. X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM) were used to characterize the structure and chemical composition of the produced samples. The M-H loops of synthesized materials were traced using a vibrating sample magnetometer (VSM) and the biocompatibility was evaluated by cell culture and MTT (3-(4,5-dimethylthiazol- 2-yl) 22,5-diphenyltetrazolium bromide) assay. Furthermore, in vivo histopathological examinations were used to evaluate the potential toxicological effects of Fe3O4-HA composites on kidney of SD rats injected intraperitoneally with Fe3O4-HA particles. The results showed that magnetic iron oxide particles first replace OH ions of HA, which are parallel to the c axis, and then enter the HA crystal lattice which produces changes in the crystal surface of HA. Chemical bond interaction was observed between PO43- groups of HA and iron ions of Fe3O4. The saturation magnetization (MS) of Fe3O4-HA composites was 46.36 emu/g obtained from VSM data. Cell culture and MTT assays indicated that HA could affect the growth and proliferation of HEK-293 cells. This Fe3O4-HA composite produced no negative effects on cell morphology, viability, and proliferation and exhibited remarkable biocompatibility. Moreover, no inflammatory cell infiltration was observed in kidney histopathology slices. Therefore, this study succeeds to develop a Fe3O4-HA composite as a prospective biomagnetic material for future applications. (c) 2013 Wiley Periodicals, Inc.

基金资助致谢
基金资助机构 授权号
National Basic Research Program of China 
2011CB710901 
NSFC 
11002016 
61227902 
10925208 
11120101001 
National Basic Research Program of China   
National Key Technology RD Program 
2012BAI18B06 
2012BAI18B05 
111 Project of China 
B13003 
International Joint Research Center of Aerospace Biotechnology and Medical Engineering   
Ministry of Science and Technology of China   
Fundamental Research Funds for the Central Universities of China   
查看基金资助信息   
出版商

WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA

类别 / 分类

研究方向:Engineering; Materials Science

Web of Science 类别:Engineering, Biomedical; Materials Science, Biomaterials

文献信息

文献类型:Article

语种:English

入藏号: WOS:000341130400038

PubMed ID: 24339231

ISSN: 1549-3296

电子 ISSN: 1552-4965

 

期刊信息

     

    其他信息

    IDS 号: AO2FD

    Web of Science 核心合集中的 "引用的参考文献": 45

    Web of Science 核心合集中的 "被引频次": 0

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